Month: January 2025

With increasing proteins concentration, inter-molecular distances reduce and protein-protein-interactions (PPIs) usually do not increase linearly but exponentially, influencing or determining mAbs solubility, aggregation, and viscosity also

With increasing proteins concentration, inter-molecular distances reduce and protein-protein-interactions (PPIs) usually do not increase linearly but exponentially, influencing or determining mAbs solubility, aggregation, and viscosity […]

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Water chromatography-mass spectroscopy determined the fact that coupling procedure substituted all 8 sites, 4 generated between cysteine residues inside the hinge region (2 per large string) and another 4 generated in cysteines that bridged the large stores to each one of the light stores in the CH1-CL region, so making a linkage that was site-specific plus some distance in the antigen-binding complementarity-determining parts of the antibody (Body 2)

Water chromatography-mass spectroscopy determined the fact that coupling procedure substituted all 8 sites, 4 generated between cysteine residues inside the hinge region (2 per large […]

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