Participants were recruited in vision care centers in Yaound. and 87%, respectively. There was no significant difference between prevalence rates of HP in the POAG and control groups. There was no association between POAG and CagA- or VacA-positive HP infection. JNJ-632 (HP) is usually a Gram-negative microaerophilic bacterium. The infection caused by this pathogen is very often asymptomatic and is correlated with low socioeconomic status.6,7 In France, 20C25% of adults are affected by this infection, while in African countries, the frequency rises as high as 95%.6,7 In Cameroon, Ndip et al estimated the prevalence rate JNJ-632 of HP in a populace of children 10 years old at 52.27%,8 whereas Ankouane et al reported a frequency of 72.5% in an adult population.9 Many researchers have suggested that = 0.03; seropositivity to HP, glaucomatous group: 68% and control group: 30%, = 0.002). Moreover, in a 2002 caseCcontrol study (41 glaucomatous participants and 30 controls) where urease screening on biopsies and serology for anti-HP immunoglobulin were carried out, a statistically significant difference was obtained between the two groups (glaucomatous group: 88%, control group: 47%, 0.001).35 Unlike these reports, no association was found between HP infection and glaucoma in our study.34,35 However, it should be noted that this prevalence rate of HP infection in glaucoma in our series is comparable to that reported in the Greek studies.34,35 It could be related to a similarity between the socioeconomic status of Greek and Cameroonian populations. Considering the CagA protein, it may be noted that its proportion JNJ-632 is very low in our sample. Thus, these results suggest that strains transporting CagA virulence protein are uncommon in our series. It has been found that HP presents a high variability in its genome.36 Kauser et al have also highlighted the diversity of circulating strains of HP in India by comparing them to those of other Asian countries.37 Tanih et al, in a study performing polymerase chain reaction analysis with specific primers Mouse monoclonal to CER1 on a sample of 254 dyspeptic patients, reported that JNJ-632 this prevalence rate of strains carrying CagA, VacA, and IceA was high and that these strains had multiple genotypic changes in South Africa.38,39 In 2008, Kurtz et al reported a lack of difference between seropositivity to HP in a caseCcontrol study (anti-CagA immunoglobulin in glaucomatous cases: 51% and controls: 52%, = 0.67).33 Our results are comparable to those of Kurtz et al, even though frequency of anti-CagA immunoglobulin is higher in their series than in ours. Our results suggest that strains responsible for the immunologic reaction in our participants are probably different. Considering anti-VacA JNJ-632 immunoglobulin, instances are very few in our sample. This shows that strains transporting the VacA virulence factor (VacA-positive strains) are less frequent than those transporting the CagA factor in our series. The proportion of participants transporting anti-VacA immunoglobulins is usually greater in glaucoma participants, although there is no significant difference between the two groups (POAG group: 6%; controls: nil). The high prevalence rate of HP infection, associated with a low frequency of seropositivity to CagA and VacA, shows that CagA- and VacA-positive strains of HP are rare in our sample. This suggests that the strains of HP responsible for the immunological reaction in our participants are less virulent, and probably less capable of contributing to digestive and extra-digestive diseases.10C18 In addition, we noticed a lack of difference between the two groups for these two virulence.
- The recommended markers for adenocarcinoma are thyroid transcription factor 1 (TTF1) and napsin A, whereas accepted antibodies for squamous differentiation include p63, p40, and cytokeratin (CK) 5/6 
- Each test run was accompanied by a 60 min column wash
- Mouth steroids could be good for disease remission also
- Type B is uncommon due to the efficiency from the conjugate polysaccharide vaccine now
- This was considered and rejected as being cost-prohibitive